| 9/11/2010 | Rose-Hulman 16 @ DePauw Tigers 45 | |
| 9/18/2010 | Kalamazoo Hornets 17 @ Rose-Hulman 41 | |
| 9/25/2010 | Rose-Hulman 31 @ Hanover Panthers 52 | † |
| 10/2/2010 | Manchester Spartans 7 @ Rose-Hulman 10 | † |
| 10/9/2010 | Rose-Hulman 17 @ Franklin Grizzlies 56 | † |
| 10/16/2010 | Rose-Hulman 13 @ Mt St Joseph Lions 7 | † |
| 10/23/2010 | Bluffton Beavers 13 @ Rose-Hulman 40 | † |
| 10/30/2010 | Rose-Hulman 21 @ Defiance Yellow Jackets 41 | † |
| 11/6/2010 | Anderson Ravens 14 @ Rose-Hulman 48 | † |
| 11/13/2010 | Earlham Hustlin' Quakers 15 @ Rose-Hulman 40 | † |