| 9/4/2010 | Bluffton 30 @ Kalamazoo Hornets 28 | |
| 9/11/2010 | Trine Thunder 76 @ Bluffton 6 | |
| 9/18/2010 | Bluffton 9 @ Franklin Grizzlies 56 | † |
| 9/25/2010 | Mt St Joseph Lions 31 @ Bluffton 10 | † |
| 10/2/2010 | Bluffton 26 @ Earlham Hustlin' Quakers 7 | † |
| 10/9/2010 | Manchester Spartans 27 @ Bluffton 29 | † |
| 10/16/2010 | Bluffton 23 @ Anderson Ravens 28 | † |
| 10/23/2010 | Bluffton 13 @ Rose-Hulman Engineers 40 | † |
| 10/30/2010 | Hanover Panthers 27 @ Bluffton 20 | † |
| 11/13/2010 | Defiance Yellow Jackets 16 @ Bluffton 21 | † |