| 9/2/2010 | Taylor Trojans 42 @ Anderson 20 | |
| 9/11/2010 | Anderson 35 @ Greenville Panthers 41 | |
| 9/18/2010 | Anderson 35 @ Mt St Joseph Lions 42 | † |
| 9/25/2010 | Anderson 56 @ Earlham Hustlin' Quakers 20 | † |
| 10/2/2010 | Hanover Panthers 28 @ Anderson 23 | † |
| 10/16/2010 | Bluffton Beavers 23 @ Anderson 28 | † |
| 10/23/2010 | Anderson 7 @ Defiance Yellow Jackets 49 | † |
| 10/30/2010 | Franklin Grizzlies 69 @ Anderson 10 | † |
| 11/6/2010 | Anderson 14 @ Rose-Hulman Engineers 48 | † |
| 11/13/2010 | Manchester Spartans 34 @ Anderson 37 | † |