| 9/2/2010 | Manchester 7 @ Trine Thunder 55 | |
| 9/11/2010 | Manchester 27 @ Kalamazoo Hornets 10 | |
| 9/18/2010 | Earlham Hustlin' Quakers 7 @ Manchester 28 | † |
| 10/2/2010 | Manchester 7 @ Rose-Hulman Engineers 10 | † |
| 10/9/2010 | Manchester 27 @ Bluffton Beavers 29 | † |
| 10/16/2010 | Franklin Grizzlies 40 @ Manchester 3 | † |
| 10/23/2010 | Hanover Panthers 35 @ Manchester 25 | † |
| 10/30/2010 | Manchester 13 @ Mt St Joseph Lions 24 | † |
| 11/6/2010 | Defiance Yellow Jackets 10 @ Manchester 7 | † |
| 11/13/2010 | Manchester 34 @ Anderson Ravens 37 | † |