| 9/4/2010 | Wilmington 7 @ Mt St Joseph Lions 24 | |
| 9/18/2010 | Capital Crusaders 10 @ Wilmington 7 | † |
| 9/25/2010 | Mount Union Purple Raiders 51 @ Wilmington 0 | † |
| 10/2/2010 | Wilmington 0 @ Muskingum Muskies 3 | † |
| 10/9/2010 | Wilmington 17 @ John Carroll Blue Streaks 38 | † |
| 10/16/2010 | Marietta Pioneers 31 @ Wilmington 28 | † |
| 10/23/2010 | Wilmington 0 @ Baldwin-Wallace Yellow Jackets 38 | † |
| 10/30/2010 | Heidelberg Fighting Student Princes 36 @ Wilmington 3 | † |
| 11/6/2010 | Wilmington 6 @ Ohio Northern Polar Bears 44 | † |
| 11/13/2010 | Otterbein Cardinals 37 @ Wilmington 14 | † |