| 9/4/2010 | Franklin Grizzlies 27 @ Carthage 30 | |
| 9/11/2010 | Carthage 35 @ Lakeland Muskies 34 | |
| 9/18/2010 | Carthage 51 @ Concordia WI Falcons 3 | |
| 10/2/2010 | Carthage 8 @ North Central Cardinals 43 | † |
| 10/9/2010 | Millikin Big Blue 24 @ Carthage 48 | † |
| 10/16/2010 | Augustana IL Vikings 43 @ Carthage 16 | † |
| 10/23/2010 | Carthage 24 @ Wheaton Thunder 31 | † |
| 10/30/2010 | North Park Vikings 10 @ Carthage 23 | † |
| 11/6/2010 | Carthage 42 @ Illinois Wesleyan Titans 49 | † |
| 11/13/2010 | Elmhurst Bluejays 6 @ Carthage 28 | † |