| 9/4/2010 | Hardin-Simmons 27 @ Whitworth Pirates 7 | |
| 9/11/2010 | Willamette Bearcats 22 @ Hardin-Simmons 31 | |
| 9/18/2010 | Mississippi College Choctaws 10 @ Hardin-Simmons 45 | † |
| 9/25/2010 | Hardin-Simmons 28 @ Mary Hardin-Baylor Crusaders 42 | † |
| 10/2/2010 | East Texas Baptist Tigers 17 @ Hardin-Simmons 49 | † |
| 10/9/2010 | Hardin-Simmons 56 @ Howard Payne Yellow Jackets 0 | † |
| 10/16/2010 | Sul Ross State Lobos 7 @ Hardin-Simmons 73 | † |
| 10/23/2010 | Hardin-Simmons 63 @ Texas Lutheran Bulldogs 17 | † |
| 10/30/2010 | McMurry 13 @ Hardin-Simmons 34 | † |
| 11/13/2010 | Hardin-Simmons 42 @ Louisiana College Wildcats 44 | † |