| 9/4/2010 | Louisiana College 34 @ Belhaven Blazers 41 | |
| 9/11/2010 | Huntingdon AL Hawks 62 @ Louisiana College 56 | |
| 9/25/2010 | Louisiana College 45 @ Mississippi College Choctaws 42 | † |
| 10/2/2010 | Mary Hardin-Baylor Crusaders 42 @ Louisiana College 38 | † |
| 10/9/2010 | Louisiana College 49 @ East Texas Baptist Tigers 21 | † |
| 10/16/2010 | Howard Payne Yellow Jackets 28 @ Louisiana College 62 | † |
| 10/23/2010 | Louisiana College 56 @ Sul Ross State Lobos 46 | † |
| 10/30/2010 | Texas Lutheran Bulldogs 21 @ Louisiana College 38 | † |
| 11/6/2010 | Louisiana College 35 @ McMurry 32 | † |
| 11/13/2010 | Hardin-Simmons Cowboys 42 @ Louisiana College 44 | † |