| 9/4/2010 | East Texas Baptist 33 @ Wisconsin-La Crosse Eagles 20 | |
| 9/11/2010 | Redlands Bulldogs 21 @ East Texas Baptist 10 | |
| 9/18/2010 | East Texas Baptist 14 @ Texas Lutheran Bulldogs 17 | † |
| 9/25/2010 | McMurry 21 @ East Texas Baptist 23 | † |
| 10/2/2010 | East Texas Baptist 17 @ Hardin-Simmons Cowboys 49 | † |
| 10/9/2010 | Louisiana College Wildcats 49 @ East Texas Baptist 21 | † |
| 10/16/2010 | East Texas Baptist 28 @ Mississippi College Choctaws 20 | † |
| 10/23/2010 | Mary Hardin-Baylor Crusaders 34 @ East Texas Baptist 28 1OT | † |
| 11/6/2010 | East Texas Baptist 24 @ Howard Payne Yellow Jackets 0 | † |
| 11/13/2010 | Sul Ross State Lobos 28 @ East Texas Baptist 47 | † |