| 9/11/2010 | Western New Mexico Mustangs 35 @ Sul Ross State 32 | |
| 9/18/2010 | Howard Payne Yellow Jackets 30 @ Sul Ross State 37 | † |
| 10/2/2010 | Sul Ross State 11 @ Texas Lutheran Bulldogs 28 | † |
| 10/9/2010 | McMurry 35 @ Sul Ross State 12 | † |
| 10/16/2010 | Sul Ross State 7 @ Hardin-Simmons Cowboys 73 | † |
| 10/23/2010 | Louisiana College Wildcats 56 @ Sul Ross State 46 | † |
| 10/30/2010 | Sul Ross State 21 @ Mississippi College Choctaws 38 | † |
| 11/6/2010 | Mary Hardin-Baylor Crusaders 76 @ Sul Ross State 12 | † |
| 11/13/2010 | Sul Ross State 28 @ East Texas Baptist Tigers 47 | † |