| 9/11/2010 | Texas Lutheran 14 @ Austin Kangaroos 20 | |
| 9/18/2010 | East Texas Baptist Tigers 14 @ Texas Lutheran 17 | † |
| 9/25/2010 | Texas Lutheran 17 @ Howard Payne Yellow Jackets 39 | † |
| 10/2/2010 | Sul Ross State Lobos 11 @ Texas Lutheran 28 | † |
| 10/9/2010 | Trinity TX Tigers 14 @ Texas Lutheran 42 | |
| 10/16/2010 | Texas Lutheran 14 @ McMurry 63 | † |
| 10/23/2010 | Hardin-Simmons Cowboys 63 @ Texas Lutheran 17 | † |
| 10/30/2010 | Texas Lutheran 21 @ Louisiana College Wildcats 38 | † |
| 11/6/2010 | Mississippi College Choctaws 23 @ Texas Lutheran 42 | † |
| 11/13/2010 | Texas Lutheran 3 @ Mary Hardin-Baylor Crusaders 81 | † |