| 9/4/2010 | Willamette 33 @ Wisconsin-Stevens Point Pointers 14 | |
| 9/11/2010 | Willamette 22 @ Hardin-Simmons Cowboys 31 | |
| 9/18/2010 | Southern Oregon Raiders 24 @ Willamette 42 | |
| 10/2/2010 | Willamette 7 @ Linfield Wildcats 35 | † |
| 10/9/2010 | Willamette 69 @ Pacific Boxers 7 | † |
| 10/16/2010 | Puget Sound Loggers 21 @ Willamette 52 | † |
| 10/23/2010 | Menlo Oaks 15 @ Willamette 32 | |
| 10/30/2010 | Willamette 28 @ Whitworth Pirates 12 | † |
| 11/6/2010 | Lewis & Clark Pioneers 24 @ Willamette 6 | † |
| 11/13/2010 | Willamette 21 @ Pacific Lutheran Lutes 24 | † |