| 9/4/2010 | Hardin-Simmons Cowboys 27 @ Whitworth 7 | |
| 9/11/2010 | Whitworth 35 @ Pomona-Pitzer Sagehens 7 | |
| 9/18/2010 | Whitworth 7 @ Redlands Bulldogs 23 | |
| 9/25/2010 | Lewis & Clark Pioneers 20 @ Whitworth 38 | † |
| 10/2/2010 | Whitworth 20 @ Menlo Oaks 7 | |
| 10/9/2010 | Whitworth 21 @ Pacific Lutheran Lutes 39 | † |
| 10/23/2010 | Whitworth 24 @ Pacific Boxers 12 | † |
| 10/30/2010 | Willamette Bearcats 28 @ Whitworth 12 | † |
| 11/6/2010 | Whitworth 17 @ Linfield Wildcats 42 | † |
| 11/13/2010 | Puget Sound Loggers 35 @ Whitworth 63 | † |