| 9/5/2010 | Lincoln PA Lions 12 vs Cheyney 0 (Philadelphia PA) | |
| 9/11/2010 | Slippery Rock Rockets 30 @ Cheyney 0 | † |
| 9/18/2010 | Edinboro Scots 27 @ Cheyney 21 | † |
| 9/25/2010 | Kutztown Golden Bears 52 @ Cheyney 14 | † |
| 10/2/2010 | Cheyney 20 @ Millersville Marauders 17 | † |
| 10/9/2010 | Bloomsburg Huskies 52 @ Cheyney 14 | † |
| 10/16/2010 | Cheyney 34 @ West Chester Golden Rams 48 | † |
| 10/23/2010 | Cheyney 0 @ Shippensburg Red Raiders 50 | † |
| 10/30/2010 | Cheyney 14 @ East Stroudsburg Warriors 58 | † |
| 11/6/2010 | C W Post Pioneers 63 @ Cheyney 28 | † |
| 11/13/2010 | Cheyney 6 @ California PA Vulcans 57 | † |