| 9/4/2010 | East Stroudsburg 57 @ Pace Setters 0 | |
| 9/11/2010 | Indiana PA Crimson Hawks 23 @ East Stroudsburg 17 | † |
| 9/18/2010 | East Stroudsburg 20 @ California PA Vulcans 45 | † |
| 9/25/2010 | West Chester Golden Rams 35 @ East Stroudsburg 31 | † |
| 10/2/2010 | East Stroudsburg 13 @ Bloomsburg Huskies 26 | † |
| 10/9/2010 | Kutztown Golden Bears 38 @ East Stroudsburg 31 | † |
| 10/16/2010 | East Stroudsburg 17 @ C W Post Pioneers 28 | † |
| 10/23/2010 | East Stroudsburg 65 @ Millersville Marauders 14 | † |
| 10/30/2010 | Cheyney Wolves 14 @ East Stroudsburg 58 | † |
| 11/6/2010 | Shippensburg Red Raiders 20 @ East Stroudsburg 17 | † |
| 11/13/2010 | East Stroudsburg 25 @ Edinboro Scots 28 | † |