| 9/4/2010 | California PA Vulcans 42 @ Saginaw Valley State 41 1OT | |
| 9/11/2010 | Saginaw Valley State 17 @ Ferris State Bulldogs 21 | † |
| 9/18/2010 | Lake Erie Storm 17 @ Saginaw Valley State 49 | † |
| 9/25/2010 | Saginaw Valley State 26 @ Northwood Timberwolves 30 | † |
| 10/2/2010 | Saginaw Valley State 21 @ Hillsdale Chargers 35 | † |
| 10/9/2010 | Michigan Tech Huskies 31 @ Saginaw Valley State 43 | † |
| 10/16/2010 | Indianapolis Greyhounds 20 @ Saginaw Valley State 24 | † |
| 10/23/2010 | Saginaw Valley State 24 @ Ashland Eagles 30 | † |
| 10/30/2010 | Wayne State MI Warriors 41 @ Saginaw Valley State 27 | † |
| 11/6/2010 | Saginaw Valley State 24 @ Northern Michigan Wildcats 17 | † |
| 11/13/2010 | Grand Valley State Lakers 28 @ Saginaw Valley State 7 | † |