| 9/2/2010 | Mayville State Comets 6 @ Minnesota-Crookston 37 | |
| 9/11/2010 | Minnesota-Crookston 6 @ Wayne State NE Warriors 68 | † |
| 9/18/2010 | Minnesota State-Mankato Mavericks 42 @ Minnesota-Crookston 3 | † |
| 9/25/2010 | Minnesota State-Moorhead Dragons 48 @ Minnesota-Crookston 18 | † |
| 10/2/2010 | Minnesota-Crookston 0 @ Mary Marauders 48 | † |
| 10/9/2010 | Minnesota-Crookston 19 @ Upper Iowa Peacocks 56 | † |
| 10/16/2010 | Northern State Wolves 38 @ Minnesota-Crookston 0 | † |
| 10/23/2010 | Minnesota-Crookston 6 @ Saint Cloud State Huskies 49 | † |
| 10/30/2010 | Concordia-St Paul Golden Bears 41 @ Minnesota-Crookston 7 | † |
| 11/6/2010 | Minnesota-Duluth Bulldogs 55 @ Minnesota-Crookston 7 | † |
| 11/13/2010 | Minnesota-Crookston 3 @ Bemidji State Beavers 45 | † |