| 9/4/2010 | Upper Iowa 10 @ Texas A&M-Commerce Lions 33 | |
| 9/11/2010 | Minnesota-Duluth Bulldogs 62 @ Upper Iowa 13 | † |
| 9/18/2010 | Upper Iowa 24 @ Minnesota State-Moorhead Dragons 28 | † |
| 9/25/2010 | Winona State Warriors 42 @ Upper Iowa 14 | † |
| 10/2/2010 | Upper Iowa 12 @ Bemidji State Beavers 51 | † |
| 10/9/2010 | Minnesota-Crookston Golden Eagles 19 @ Upper Iowa 56 | † |
| 10/16/2010 | Upper Iowa 14 @ Minnesota State-Mankato Mavericks 48 | † |
| 10/23/2010 | Southwest Minnesota State Mustangs 40 @ Upper Iowa 34 1OT | † |
| 10/30/2010 | Wayne State NE Warriors 20 @ Upper Iowa 21 | † |
| 11/6/2010 | Upper Iowa 7 @ Concordia-St Paul Golden Bears 56 | † |
| 11/13/2010 | Upper Iowa 0 @ Augustana SD Vikings 32 | † |