| 9/4/2010 | Saint Cloud State 23 @ Augustana SD Vikings 32 | † |
| 9/11/2010 | Saint Cloud State 35 @ Concordia-St Paul Golden Bears 10 | † |
| 9/18/2010 | Winona State Warriors 26 @ Saint Cloud State 31 | † |
| 9/25/2010 | Mary Marauders 13 @ Saint Cloud State 30 | † |
| 10/2/2010 | Saint Cloud State 42 @ Northern State Wolves 10 | † |
| 10/9/2010 | Saint Cloud State 31 @ Minnesota State-Mankato Mavericks 17 | † |
| 10/16/2010 | Southwest Minnesota State Mustangs 6 @ Saint Cloud State 24 | † |
| 10/23/2010 | Minnesota-Crookston Golden Eagles 6 @ Saint Cloud State 49 | † |
| 10/30/2010 | Saint Cloud State 17 @ Minnesota-Duluth Bulldogs 40 | † |
| 11/6/2010 | Bemidji State Beavers 14 @ Saint Cloud State 35 | † |
| 11/13/2010 | Saint Cloud State 42 @ Minnesota State-Moorhead Dragons 16 | † |
| 11/20/2010 | Hillsdale Chargers 28 @ Saint Cloud State 42 | |
| 11/27/2010 | Saint Cloud State 17 @ Minnesota-Duluth Bulldogs 20 1OT | † |