| 9/2/2010 | Northern Michigan Wildcats 6 @ Minnesota State-Mankato 7 | |
| 9/11/2010 | Minnesota State-Mankato 21 @ Northern State Wolves 14 | † |
| 9/18/2010 | Minnesota State-Mankato 42 @ Minnesota-Crookston Golden Eagles 3 | † |
| 9/25/2010 | Concordia-St Paul Golden Bears 28 @ Minnesota State-Mankato 26 | † |
| 10/2/2010 | Minnesota State-Mankato 21 @ Winona State Warriors 43 | † |
| 10/9/2010 | Saint Cloud State Huskies 31 @ Minnesota State-Mankato 17 | † |
| 10/16/2010 | Upper Iowa Peacocks 14 @ Minnesota State-Mankato 48 | † |
| 10/23/2010 | Minnesota State-Mankato 13 @ Wayne State NE Warriors 3 | † |
| 10/30/2010 | Minnesota State-Mankato 13 @ Augustana SD Vikings 17 | † |
| 11/6/2010 | Southwest Minnesota State Mustangs 7 @ Minnesota State-Mankato 53 | † |
| 11/15/2010 | Minnesota-Duluth Bulldogs 45 @ Minnesota State-Mankato 21 (Marshall MN) | † |