| 8/26/2010 | Minnesota State-Moorhead 0 @ Missouri Southern Lions 30 | |
| 9/11/2010 | Minnesota State-Moorhead 3 @ Winona State Warriors 58 | † |
| 9/18/2010 | Upper Iowa Peacocks 24 @ Minnesota State-Moorhead 28 | † |
| 9/25/2010 | Minnesota State-Moorhead 48 @ Minnesota-Crookston Golden Eagles 18 | † |
| 10/2/2010 | Minnesota-Duluth Bulldogs 56 @ Minnesota State-Moorhead 7 | † |
| 10/9/2010 | Minnesota State-Moorhead 14 @ Southwest Minnesota State Mustangs 49 | † |
| 10/16/2010 | Bemidji State Beavers 14 @ Minnesota State-Moorhead 6 | † |
| 10/23/2010 | Augustana SD Vikings 47 @ Minnesota State-Moorhead 17 | † |
| 10/30/2010 | Minnesota State-Moorhead 17 @ Mary Marauders 43 | † |
| 11/6/2010 | Minnesota State-Moorhead 7 @ Northern State Wolves 16 | † |
| 11/13/2010 | Saint Cloud State Huskies 42 @ Minnesota State-Moorhead 16 | † |