| 8/28/2010 | Mary 3 @ Chadron State Eagles 35 | |
| 9/11/2010 | Southwest Minnesota State Mustangs 21 @ Mary 14 | † |
| 9/18/2010 | Mary 21 @ Augustana SD Vikings 52 | † |
| 9/25/2010 | Mary 13 @ Saint Cloud State Huskies 30 | † |
| 10/2/2010 | Minnesota-Crookston Golden Eagles 0 @ Mary 48 | † |
| 10/9/2010 | Wayne State NE Warriors 33 @ Mary 28 | † |
| 10/16/2010 | Mary 0 @ Minnesota-Duluth Bulldogs 49 | † |
| 10/23/2010 | Mary 22 @ Bemidji State Beavers 23 | † |
| 10/30/2010 | Minnesota State-Moorhead Dragons 17 @ Mary 43 | † |
| 11/6/2010 | Mary 21 @ Winona State Warriors 19 | † |
| 11/13/2010 | Northern State Wolves 3 @ Mary 48 | † |