| 9/4/2010 | Minot State Beavers 17 @ Concordia-St Paul 38 | |
| 9/11/2010 | Saint Cloud State Huskies 35 @ Concordia-St Paul 10 | † |
| 9/18/2010 | Concordia-St Paul 27 @ Northern State Wolves 17 | † |
| 9/25/2010 | Concordia-St Paul 28 @ Minnesota State-Mankato Mavericks 26 | † |
| 10/2/2010 | Augustana SD Vikings 22 @ Concordia-St Paul 16 | † |
| 10/9/2010 | Bemidji State Beavers 14 @ Concordia-St Paul 20 | † |
| 10/16/2010 | Concordia-St Paul 17 @ Wayne State NE Warriors 14 | † |
| 10/23/2010 | Winona State Warriors 31 @ Concordia-St Paul 28 | † |
| 10/30/2010 | Concordia-St Paul 41 @ Minnesota-Crookston Golden Eagles 7 | † |
| 11/6/2010 | Upper Iowa Peacocks 7 @ Concordia-St Paul 56 | † |
| 11/13/2010 | Concordia-St Paul 32 @ Southwest Minnesota State Mustangs 14 | † |
| 12/4/2010 | Pittsburg State Gorillas 13 vs Concordia-St Paul 9 (Excelsior Springs MO) |