| 8/28/2010 | Wayne State NE 24 @ Nebraska-Kearney Lopers 17 | |
| 9/11/2010 | Minnesota-Crookston Golden Eagles 6 @ Wayne State NE 68 | † |
| 9/18/2010 | Wayne State NE 10 @ Minnesota-Duluth Bulldogs 42 | † |
| 9/25/2010 | Northern State Wolves 20 @ Wayne State NE 44 | † |
| 10/2/2010 | Wayne State NE 38 @ Southwest Minnesota State Mustangs 20 | † |
| 10/9/2010 | Wayne State NE 33 @ Mary Marauders 28 | † |
| 10/16/2010 | Concordia-St Paul Golden Bears 17 @ Wayne State NE 14 | † |
| 10/23/2010 | Minnesota State-Mankato Mavericks 13 @ Wayne State NE 3 | † |
| 10/30/2010 | Wayne State NE 20 @ Upper Iowa Peacocks 21 | † |
| 11/6/2010 | Augustana SD Vikings 14 @ Wayne State NE 26 | † |
| 11/13/2010 | Wayne State NE 13 @ Winona State Warriors 24 | † |