| 8/28/2010 | Minnesota-Duluth 35 @ Central Washington Wildcats 10 | |
| 9/11/2010 | Minnesota-Duluth 62 @ Upper Iowa Peacocks 13 | † |
| 9/18/2010 | Wayne State NE Warriors 10 @ Minnesota-Duluth 42 | † |
| 9/25/2010 | Bemidji State Beavers 21 @ Minnesota-Duluth 44 | † |
| 10/2/2010 | Minnesota-Duluth 56 @ Minnesota State-Moorhead Dragons 7 | † |
| 10/9/2010 | Winona State Warriors 17 @ Minnesota-Duluth 59 | † |
| 10/16/2010 | Mary Marauders 0 @ Minnesota-Duluth 49 | † |
| 10/23/2010 | Minnesota-Duluth 27 @ Northern State Wolves 7 | † |
| 10/30/2010 | Saint Cloud State Huskies 17 @ Minnesota-Duluth 40 | † |
| 11/6/2010 | Minnesota-Duluth 55 @ Minnesota-Crookston Golden Eagles 7 | † |
| 11/15/2010 | Minnesota-Duluth 45 @ Minnesota State-Mankato Mavericks 21 (Marshall MN) | † |
| 11/27/2010 | Saint Cloud State Huskies 17 @ Minnesota-Duluth 20 1OT | † |
| 12/4/2010 | Augustana SD Vikings 6 @ Minnesota-Duluth 25 | † |
| 12/11/2010 | Northwest Missouri State Bearcats @ Minnesota-Duluth | |
| 12/18/2010 | Delta State Statesmen 17 vs Minnesota-Duluth 20 (Florence AL - D2 Championship) |