| 9/2/2010 | Texas A&M-Kingsville Javelinas 16 @ Northwest Missouri State 7 | |
| 9/18/2010 | Northwest Missouri State 58 @ Nebraska-Omaha Mavericks 23 | † |
| 9/25/2010 | Northwest Missouri State 44 @ Truman State Bulldogs 10 | † |
| 10/2/2010 | Missouri Western Griffons 0 @ Northwest Missouri State 42 | † |
| 10/9/2010 | Northwest Missouri State 49 @ Missouri Southern Lions 21 | † |
| 10/16/2010 | Emporia State Hornets 28 @ Northwest Missouri State 42 | † |
| 10/23/2010 | Northwest Missouri State 41 @ Washburn Ichabods 40 | † |
| 10/30/2010 | Fort Hays State Tigers 27 @ Northwest Missouri State 45 | † |
| 11/6/2010 | Northwest Missouri State 17 @ Central Missouri Mules 16 | † |
| 11/15/2010 | Northwest Missouri State 22 vs Pittsburg State Gorillas 16 (Kansas City MO) | † |
| 11/20/2010 | Missouri Western Griffons 24 @ Northwest Missouri State 28 | † |
| 11/27/2010 | Northwest Missouri State 35 @ Texas A&M-Kingsville Javelinas 31 | |
| 12/4/2010 | Central Missouri Mules 20 @ Northwest Missouri State 37 | † |
| 12/11/2010 | Northwest Missouri State @ Minnesota-Duluth Bulldogs |