| 8/28/2010 | Winona State 24 @ Carson-Newman Eagles 21 | |
| 9/11/2010 | Minnesota State-Moorhead Dragons 3 @ Winona State 58 | † |
| 9/18/2010 | Winona State 26 @ Saint Cloud State Huskies 31 | † |
| 9/25/2010 | Winona State 42 @ Upper Iowa Peacocks 14 | † |
| 10/2/2010 | Minnesota State-Mankato Mavericks 21 @ Winona State 43 | † |
| 10/9/2010 | Winona State 17 @ Minnesota-Duluth Bulldogs 59 | † |
| 10/16/2010 | Augustana SD Vikings 17 @ Winona State 0 | † |
| 10/23/2010 | Winona State 31 @ Concordia-St Paul Golden Bears 28 | † |
| 10/30/2010 | Winona State 44 @ Southwest Minnesota State Mustangs 19 | † |
| 11/6/2010 | Mary Marauders 21 @ Winona State 19 | † |
| 11/13/2010 | Wayne State NE Warriors 13 @ Winona State 24 | † |