| 9/4/2010 | William Jewell 0 @ Benedictine KS Ravens 21 | † |
| 9/11/2010 | Graceland Yellow Jackets 9 @ William Jewell 31 | † |
| 9/18/2010 | William Jewell 14 @ Southwest Baptist Bearcats 59 | |
| 9/25/2010 | William Jewell 25 @ Evangel Crusaders 28 | † |
| 10/2/2010 | Central Methodist Eagles 3 @ William Jewell 13 | † |
| 10/9/2010 | William Jewell 23 @ Missouri Valley Vikings 40 | † |
| 10/16/2010 | MidAmerica Nazarene Pioneers 29 @ William Jewell 7 | † |
| 10/23/2010 | William Jewell 41 @ Avila Eagles 13 | † |
| 10/30/2010 | Baker Wildcats 12 @ William Jewell 9 | † |
| 11/6/2010 | William Jewell 21 @ Culver-Stockton Wildcats 13 | † |
| 11/13/2010 | Lindenwood Lions 29 @ William Jewell 18 | † |