| 9/2/2010 | Lambuth Eagles 19 @ Arkansas Tech 34 | |
| 9/9/2010 | Arkansas Tech 25 @ Delta State Statesmen 27 | † |
| 9/18/2010 | Henderson State Reddies 45 @ Arkansas Tech 21 | † |
| 9/25/2010 | Arkansas Tech 30 @ Arkansas-Monticello Boll Weevils 25 | † |
| 10/2/2010 | Arkansas Tech 0 @ North Alabama Lions 28 | † |
| 10/9/2010 | Oauchita Tigers 28 @ Arkansas Tech 6 | † |
| 10/16/2010 | Southern Arkansas Muleriders 19 @ Arkansas Tech 35 | † |
| 10/23/2010 | Arkansas Tech 26 @ West Alabama Tigers 49 | † |
| 10/30/2010 | Valdosta State Blazers 21 @ Arkansas Tech 7 | † |
| 11/6/2010 | Arkansas Tech 7 @ Harding Bison 42 | † |
| 11/13/2010 | Southwest Baptist Bearcats 14 @ Arkansas Tech 42 |