| 8/28/2010 | Southern Nazarene 21 @ Eastern New Mexico Greyhounds 59 | |
| 9/4/2010 | St Mary KS Spires 17 @ Southern Nazarene 63 | |
| 9/11/2010 | Southern Nazarene 70 @ Haskell Indians 0 | |
| 9/18/2010 | Southern Nazarene 42 @ Bethel KS Threshers 18 | |
| 9/25/2010 | Southwest Baptist Bearcats 69 @ Southern Nazarene 27 | |
| 10/2/2010 | Southwestern Assemblies of God Lions 21 @ Southern Nazarene 35 | † |
| 10/9/2010 | Northwestern Oklahoma State Rangers 62 @ Southern Nazarene 52 | † |
| 10/23/2010 | Southern Nazarene 52 @ Texas College Steers 49 | † |
| 10/30/2010 | Panhandle State Aggies 34 @ Southern Nazarene 31 | |
| 11/6/2010 | Southern Nazarene 41 @ Bacone Warriors 19 | † |
| 11/13/2010 | Langston Lions 27 @ Southern Nazarene 30 | † |