| 9/4/2010 | Nebraska-Kearney Lopers 32 @ Nebraska-Omaha 29 | |
| 9/9/2010 | Oauchita Tigers 38 @ Nebraska-Omaha 23 | |
| 9/18/2010 | Northwest Missouri State Bearcats 58 @ Nebraska-Omaha 23 | † |
| 9/25/2010 | Missouri Southern Lions 10 @ Nebraska-Omaha 42 | † |
| 10/2/2010 | Emporia State Hornets 17 @ Nebraska-Omaha 42 | † |
| 10/9/2010 | Nebraska-Omaha 28 @ Washburn Ichabods 40 | † |
| 10/16/2010 | Fort Hays State Tigers 29 @ Nebraska-Omaha 41 | † |
| 10/23/2010 | Nebraska-Omaha 31 @ Central Missouri Mules 34 | † |
| 10/30/2010 | Nebraska-Omaha 48 @ Pittsburg State Gorillas 27 | † |
| 11/6/2010 | Missouri Western Griffons 16 @ Nebraska-Omaha 14 | † |
| 11/13/2010 | Nebraska-Omaha 62 @ Truman State Bulldogs 61 | † |