| 8/26/2010 | Minnesota State-Moorhead Dragons 0 @ Missouri Southern 30 | |
| 9/4/2010 | Lincoln MO Blue Tigers 7 @ Missouri Southern 38 | |
| 9/18/2010 | Missouri Southern 27 @ Emporia State Hornets 30 | † |
| 9/25/2010 | Missouri Southern 10 @ Nebraska-Omaha Mavericks 42 | † |
| 10/2/2010 | Missouri Southern 21 @ Pittsburg State Gorillas 24 | † |
| 10/9/2010 | Northwest Missouri State Bearcats 49 @ Missouri Southern 21 | † |
| 10/16/2010 | Missouri Southern 6 @ Truman State Bulldogs 23 | † |
| 10/23/2010 | Missouri Western Griffons 6 @ Missouri Southern 23 | † |
| 10/30/2010 | Central Missouri Mules 34 @ Missouri Southern 21 | † |
| 11/6/2010 | Missouri Southern 41 @ Fort Hays State Tigers 31 | † |
| 11/13/2010 | Washburn Ichabods 23 @ Missouri Southern 7 | † |