| 9/2/2010 | Mesa State Mavericks 3 @ Missouri Western 36 | |
| 9/9/2010 | Lincoln MO Blue Tigers 14 @ Missouri Western 81 | |
| 9/18/2010 | Missouri Western 36 @ Washburn Ichabods 33 | † |
| 9/25/2010 | Pittsburg State Gorillas 25 @ Missouri Western 42 | † |
| 10/2/2010 | Missouri Western 0 @ Northwest Missouri State Bearcats 42 | † |
| 10/9/2010 | Truman State Bulldogs 7 @ Missouri Western 29 | † |
| 10/16/2010 | Missouri Western 21 @ Central Missouri Mules 43 | † |
| 10/23/2010 | Missouri Western 6 @ Missouri Southern Lions 23 | † |
| 10/30/2010 | Emporia State Hornets 14 @ Missouri Western 42 | † |
| 11/6/2010 | Missouri Western 16 @ Nebraska-Omaha Mavericks 14 | † |
| 11/13/2010 | Fort Hays State Tigers 21 @ Missouri Western 48 | † |
| 11/20/2010 | Missouri Western 24 @ Northwest Missouri State Bearcats 28 | † |