| 8/28/2010 | Pittsburg State 31 @ Central Oklahoma Bronchos 20 | |
| 9/4/2010 | Chadron State Eagles 3 @ Pittsburg State 14 | |
| 9/18/2010 | Central Missouri Mules 37 @ Pittsburg State 20 | † |
| 9/25/2010 | Pittsburg State 25 @ Missouri Western Griffons 42 | † |
| 10/2/2010 | Missouri Southern Lions 21 @ Pittsburg State 24 | † |
| 10/9/2010 | Pittsburg State 14 @ Emporia State Hornets 17 | † |
| 10/16/2010 | Washburn Ichabods 35 @ Pittsburg State 34 2OT | † |
| 10/23/2010 | Pittsburg State 38 @ Fort Hays State Tigers 21 | † |
| 10/30/2010 | Nebraska-Omaha Mavericks 48 @ Pittsburg State 27 | † |
| 11/6/2010 | Truman State Bulldogs 14 @ Pittsburg State 17 | † |
| 11/15/2010 | Northwest Missouri State Bearcats 22 vs Pittsburg State 16 (Kansas City MO) | † |
| 12/4/2010 | Pittsburg State 13 vs Concordia-St Paul Golden Bears 9 (Excelsior Springs MO) |