| 9/4/2010 | Upper Iowa Peacocks 10 @ Texas A&M-Commerce 33 | |
| 9/11/2010 | Angelo State Rams 31 vs Texas A&M-Commerce 10 (Dallas TX) | † |
| 9/18/2010 | Texas A&M-Commerce 0 @ Texas A&M-Kingsville Javelinas 21 | † |
| 9/25/2010 | Texas A&M-Commerce 21 @ Eastern New Mexico Greyhounds 44 | † |
| 10/2/2010 | Southeastern Oklahoma State Savage Storm 14 @ Texas A&M-Commerce 19 | † |
| 10/9/2010 | Texas A&M-Commerce 7 @ Northeastern State Riverhawks 38 | † |
| 10/16/2010 | Tarleton State Texans 34 @ Texas A&M-Commerce 31 | † |
| 10/24/2010 | Southwestern Oklahoma State Bulldogs 24 @ Texas A&M-Commerce 10 | † |
| 10/30/2010 | Texas A&M-Commerce 31 @ Central Oklahoma Bronchos 30 | † |
| 11/6/2010 | East Central Tigers 36 @ Texas A&M-Commerce 33 | † |
| 11/13/2010 | Texas A&M-Commerce 16 @ Incarnate Word Cardinals 17 | † |