| 8/28/2010 | Pittsburg State Gorillas 31 @ Central Oklahoma 20 | |
| 9/11/2010 | Tarleton State Texans 21 @ Central Oklahoma 37 | † |
| 9/18/2010 | Central Oklahoma 41 @ Incarnate Word Cardinals 42 | † |
| 9/25/2010 | Midwestern State Mustangs 30 @ Central Oklahoma 24 | † |
| 10/2/2010 | East Central Tigers 28 @ Central Oklahoma 31 | † |
| 10/9/2010 | Central Oklahoma 31 @ Eastern New Mexico Greyhounds 49 | † |
| 10/16/2010 | Southeastern Oklahoma State Savage Storm 56 @ Central Oklahoma 55 1OT | † |
| 10/23/2010 | Central Oklahoma 28 @ Northeastern State Riverhawks 39 | † |
| 10/30/2010 | Texas A&M-Commerce Lions 31 @ Central Oklahoma 30 | † |
| 11/6/2010 | Central Oklahoma 24 @ Southwestern Oklahoma State Bulldogs 31 | † |
| 11/13/2010 | Central Oklahoma 35 @ Angelo State Rams 49 | † |