| 9/4/2010 | Mississippi Valley State Delta Devils 6 @ Alabama State 34 | † |
| 9/11/2010 | Ark Pine Bluff Golden Lions 31 @ Alabama State 38 | † |
| 9/18/2010 | Alabama State 18 @ Prairie View Panthers 15 | † |
| 9/25/2010 | Alabama State 21 @ Alcorn State Braves 41 | † |
| 10/2/2010 | Texas Southern Tigers 21 @ Alabama State 7 | † |
| 10/9/2010 | Alabama State 7 @ Grambling Tigers 22 | † |
| 10/23/2010 | Savannah State Tigers 0 @ Alabama State 24 | |
| 10/30/2010 | Alabama State 31 vs Alabama A&M Bulldogs 10 (Birmingham AL) | † |
| 11/6/2010 | Jackson State Tigers 30 @ Alabama State 32 | † |
| 11/13/2010 | Alabama State 21 @ Southern Jaquars 19 | † |
| 11/25/2010 | Tuskegee Golden Tigers 17 @ Alabama State 10 | |
| 12/11/2010 | Alabama State 6 vs Texas Southern Tigers 11 (Birmingham AL) | † |