| 9/5/2010 | Texas Southern Tigers 14 @ Prairie View 16 | † |
| 9/11/2010 | Prairie View 7 @ Southern Miss Golden Eagles 34 | |
| 9/18/2010 | Alabama State Hornets 18 @ Prairie View 15 | † |
| 9/25/2010 | Grambling Tigers 34 vs Prairie View 17 (Dallas TX) | † |
| 10/2/2010 | Prairie View 34 @ Mississippi Valley State Delta Devils 13 | † |
| 10/7/2010 | Prairie View 21 @ Ark Pine Bluff Golden Lions 6 | † |
| 10/16/2010 | Lincoln MO Blue Tigers 12 @ Prairie View 45 | |
| 10/23/2010 | Prairie View 30 vs Southern Jaquars 16 (Shreveport LA) | † |
| 10/30/2010 | Prairie View 13 @ Jackson State Tigers 30 | † |
| 11/13/2010 | Alcorn State Braves 27 @ Prairie View 35 | † |
| 11/20/2010 | Prairie View 35 @ Alabama A&M Bulldogs 14 | † |