| 9/4/2010 | Monmouth NJ Hawks 29 @ Colgate 30 | |
| 9/11/2010 | Colgate 15 @ Furman Paladins 45 | |
| 9/25/2010 | Colgate 7 @ Syracuse Orangemen 42 | |
| 10/2/2010 | Georgetown Hoyas 3 @ Colgate 34 | † |
| 10/9/2010 | Colgate 44 @ Princeton Tigers 10 | |
| 10/16/2010 | Colgate 44 @ Cornell Rams 3 | |
| 10/23/2010 | Holy Cross Crusaders 31 @ Colgate 24 | † |
| 10/30/2010 | Colgate 14 @ Lehigh Mountain Hawks 44 | † |
| 11/6/2010 | Lafayette Leopards 14 @ Colgate 24 | † |
| 11/13/2010 | Colgate 31 @ Bucknell Bison 7 | † |
| 11/20/2010 | Colgate 47 @ Fordham Rams 12 | † |