| 9/2/2010 | Albany NY Great Danes 3 @ Maine 0 | |
| 9/11/2010 | Maine 31 @ Monmouth NJ Hawks 23 | |
| 9/18/2010 | Maine 14 @ Syracuse Orangemen 38 | |
| 9/25/2010 | William & Mary Tribe 24 @ Maine 21 | † |
| 10/2/2010 | New Hampshire Wildcats 13 @ Maine 16 1OT | † |
| 10/9/2010 | Maine 7 @ Delaware Blue Hens 26 | † |
| 10/16/2010 | Villanova Wildcats 48 @ Maine 18 | † |
| 10/23/2010 | Maine 28 @ Rhode Island Rams 23 | † |
| 11/6/2010 | Maine 24 @ Massachusetts Minutemen 39 | † |
| 11/13/2010 | Maine 28 @ Towson Tigers 18 | † |
| 11/20/2010 | James Madison Dukes 14 @ Maine 10 | † |