| 9/4/2010 | St Joseph's Pumas 7 @ Indiana State 57 | |
| 9/11/2010 | Indiana State 7 @ Cincinnati Bearcats 40 | |
| 9/25/2010 | Indiana State 7 @ Western Illinois Leathernecks 40 | † |
| 10/2/2010 | Quincy Hawks 22 @ Indiana State 56 | |
| 10/9/2010 | Illinois State Redbirds 24 @ Indiana State 59 | † |
| 10/16/2010 | Missouri State Bears 35 @ Indiana State 38 | † |
| 10/23/2010 | Indiana State 15 @ North Dakota State Bison 27 | † |
| 10/30/2010 | South Dakota State Jackrabbits 30 @ Indiana State 41 | † |
| 11/6/2010 | Northern Iowa Panthers 30 @ Indiana State 20 | † |
| 11/13/2010 | Indiana State 30 @ Youngstown State Penguins 24 | † |
| 11/20/2010 | Indiana State 21 @ Southern Illinois Salukis 49 | † |