| 9/3/2005 | Murray St | 6 | @ | Mississippi St | 38 | ||||
| 9/17/2005 | Indiana St | 15 | @ | Murray St | 27 | ||||
| 9/24/2005 | Murray St | 0 | @ | Illinois St | 42 | ||||
| 10/1/2005 | Murray St | 21 | @ | Tennessee Tech | 42 | OVC | |||
| 10/8/2005 | Jacksonville St | 28 | @ | Murray St | 23 | OVC | |||
| 10/15/2005 | Murray St | 23 | @ | Samford | 27 | OVC | |||
| 10/22/2005 | Eastern Illinois | 32 | @ | Murray St | 33 | OVC | |||
| 10/29/2005 | Murray St | 21 | @ | SE Missouri St | 52 | OVC | |||
| 11/5/2005 | Eastern Kentucky | 43 | @ | Murray St | 7 | OVC | |||
| 11/12/2005 | Austin Peay | 6 | @ | Murray St | 42 | ||||
| 11/17/2005 | Murray St | 20 | @ | Tennessee-Martin | 49 | OVC |