| 9/3/2005 | Appalachian St | 24 | @ | Eastern Kentucky | 16 | ||||
| 9/10/2005 | Eastern Kentucky | 21 | @ | Western Kentucky | 23 | ||||
| 9/17/2005 | Eastern Kentucky | 10 | @ | North Carolina St | 54 | ||||
| 9/24/2005 | Tennessee Tech | 3 | @ | Eastern Kentucky | 52 | OVC | |||
| 10/1/2005 | Eastern Kentucky | 14 | @ | Jacksonville St | 31 | OVC | |||
| 10/8/2005 | Samford | 6 | @ | Eastern Kentucky | 38 | OVC | |||
| 10/15/2005 | Eastern Kentucky | 22 | @ | Eastern Illinois | 53 | OVC | |||
| 10/22/2005 | SE Missouri St | 33 | @ | Eastern Kentucky | 32 | OVC | |||
| 11/5/2005 | Eastern Kentucky | 43 | @ | Murray St | 7 | OVC | |||
| 11/12/2005 | Tennessee-Martin | 17 | @ | Eastern Kentucky | 31 | OVC | |||
| 11/19/2005 | Eastern Kentucky | 49 | @ | Tennessee St | 10 | OVC |