| 9/1/2005 | Eastern Illinois | 24 | @ | Indiana St | 13 | ||||
| 9/10/2005 | Eastern Illinois | 10 | @ | BYU | 45 | ||||
| 9/17/2005 | Illinois St | 27 | @ | Eastern Illinois | 6 | ||||
| 9/24/2005 | Samford | 14 | @ | Eastern Illinois | 43 | OVC | |||
| 10/8/2005 | Eastern Illinois | 48 | @ | SE Missouri St | 24 | OVC | |||
| 10/15/2005 | Eastern Kentucky | 22 | @ | Eastern Illinois | 53 | OVC | |||
| 10/22/2005 | Eastern Illinois | 32 | @ | Murray St | 33 | OVC | |||
| 10/29/2005 | Tennessee-Martin | 7 | @ | Eastern Illinois | 26 | OVC | |||
| 11/5/2005 | Eastern Illinois | 27 | @ | Tennessee St | 3 | OVC | |||
| 11/12/2005 | Tennessee Tech | 20 | @ | Eastern Illinois | 31 | OVC | |||
| 11/19/2005 | Eastern Illinois | 10 | @ | Jacksonville St | 6 | OVC |