| 9/3/2005 | Illinois St | 21 | @ | Iowa State | 32 | ||||
| 9/10/2005 | Drake | 19 | @ | Illinois St | 56 | ||||
| 9/17/2005 | Illinois St | 27 | @ | Eastern Illinois | 6 | ||||
| 9/24/2005 | Murray St | 0 | @ | Illinois St | 42 | ||||
| 10/1/2005 | Illinois St | 17 | @ | Youngstown St | 20 | GW | |||
| 10/8/2005 | Western Kentucky | 37 | @ | Illinois St | 34 | GW | |||
| 10/15/2005 | Illinois St | 61 | @ | Southern Illinois | 35 | GW | |||
| 10/22/2005 | Northern Iowa | 3 | @ | Illinois St | 38 | GW | |||
| 10/29/2005 | Western Illinois | 31 | @ | Illinois St | 17 | GW | |||
| 11/5/2005 | Illinois St | 48 | @ | Missouri State | 23 | GW | |||
| 11/12/2005 | Indiana St | 28 | @ | Illinois St | 70 | GW |