| 9/3/2005 | Murray St | 6 | @ | Mississippi St | 38 | ||||
| 9/10/2005 | Mississippi St | 0 | @ | #7 Auburn | 28 | SEC | |||
| 9/17/2005 | Mississippi St | 21 | @ | Tulane | 14 | ||||
| 9/24/2005 | #8 Georgia | 23 | @ | Mississippi St | 10 | SEC | |||
| 10/1/2005 | #10 LSU | 37 | @ | Mississippi St | 7 | SEC | |||
| 10/8/2005 | Mississippi St | 9 | @ | #16 Florida | 35 | SEC | |||
| 10/22/2005 | Houston | 28 | @ | Mississippi St | 16 | ||||
| 10/29/2005 | Mississippi St | 7 | @ | Kentucky | 13 | SEC | |||
| 11/5/2005 | #13 Alabama | 17 | @ | Mississippi St | 0 | SEC | |||
| 11/19/2005 | Mississippi St | 10 | @ | Arkansas | 44 | SEC | Little Rock AR | ||
| 11/26/2005 | Mississippi | 14 | @ | Mississippi St | 35 | SEC |