| 9/1/2005 | Edward Waters | 7 | @ | Samford | 60 | ||||
| 9/10/2005 | Samford | 14 | @ | Baylor | 48 | ||||
| 9/17/2005 | Samford | 23 | @ | Furman | 45 | ||||
| 9/24/2005 | Samford | 14 | @ | Eastern Illinois | 43 | OVC | |||
| 9/29/2005 | SE Missouri St | 17 | @ | Samford | 33 | OVC | |||
| 10/8/2005 | Samford | 6 | @ | Eastern Kentucky | 38 | OVC | |||
| 10/15/2005 | Murray St | 23 | @ | Samford | 27 | OVC | |||
| 10/22/2005 | Samford | 30 | @ | Tennessee-Martin | 22 | OVC | |||
| 10/29/2005 | Tennessee St | 11 | @ | Samford | 31 | OVC | |||
| 11/5/2005 | Samford | 21 | @ | Tennessee Tech | 42 | OVC | |||
| 11/12/2005 | Jacksonville St | 26 | @ | Samford | 20 | OVC |