| 9/1/2005 | Southern Illinois | 58 | @ | SE Missouri St | 23 | ||||
| 9/10/2005 | SE Missouri St | 12 | @ | Kent St | 33 | ||||
| 9/17/2005 | SE Missouri St | 21 | @ | Missouri State | 45 | ||||
| 9/24/2005 | Jacksonville St | 24 | @ | SE Missouri St | 10 | OVC | |||
| 9/29/2005 | SE Missouri St | 17 | @ | Samford | 33 | OVC | |||
| 10/8/2005 | Eastern Illinois | 48 | @ | SE Missouri St | 24 | OVC | |||
| 10/22/2005 | SE Missouri St | 33 | @ | Eastern Kentucky | 32 | OVC | |||
| 10/29/2005 | Murray St | 21 | @ | SE Missouri St | 52 | OVC | |||
| 11/5/2005 | SE Missouri St | 21 | @ | Tennessee-Martin | 24 | OVC | |||
| 11/12/2005 | Tennessee St | 24 | @ | SE Missouri St | 32 | OVC | |||
| 11/19/2005 | SE Missouri St | 24 | @ | Tennessee Tech | 31 | OVC |