| 9/3/2005 | Tennessee Tech | 23 | @ | Chattanooga | 30 | OT | |||
| 9/8/2005 | Lambuth | 10 | @ | Tennessee Tech | 52 | ||||
| 9/17/2005 | Tennessee Tech | 3 | @ | Northern Illinois | 42 | ||||
| 9/24/2005 | Tennessee Tech | 3 | @ | Eastern Kentucky | 52 | OVC | |||
| 10/1/2005 | Murray St | 21 | @ | Tennessee Tech | 42 | OVC | |||
| 10/8/2005 | Tennessee Tech | 16 | @ | Tennessee-Martin | 46 | OVC | |||
| 10/13/2005 | Tennessee St | 31 | @ | Tennessee Tech | 20 | OVC | |||
| 10/29/2005 | Tennessee Tech | 7 | @ | Jacksonville St | 30 | OVC | |||
| 11/5/2005 | Samford | 21 | @ | Tennessee Tech | 42 | OVC | |||
| 11/12/2005 | Tennessee Tech | 20 | @ | Eastern Illinois | 31 | OVC | |||
| 11/19/2005 | SE Missouri St | 24 | @ | Tennessee Tech | 31 | OVC |