| 9/1/2005 | Eastern Illinois | 24 | @ | Indiana St | 13 | ||||
| 9/10/2005 | St Francis IN | 42 | @ | Indiana St | 10 | ||||
| 9/17/2005 | Indiana St | 15 | @ | Murray St | 27 | ||||
| 9/24/2005 | Indiana St | 7 | @ | #15 Texas Tech | 63 | ||||
| 10/1/2005 | Western Kentucky | 38 | @ | Indiana St | 28 | GW | |||
| 10/8/2005 | Youngstown St | 45 | @ | Indiana St | 0 | GW | |||
| 10/15/2005 | Indiana St | 10 | @ | Northern Iowa | 31 | GW | |||
| 10/22/2005 | Southern Illinois | 42 | @ | Indiana St | 20 | GW | |||
| 10/29/2005 | Indiana St | 27 | @ | Missouri State | 31 | GW | |||
| 11/5/2005 | Western Illinois | 63 | @ | Indiana St | 35 | GW | |||
| 11/12/2005 | Indiana St | 28 | @ | Illinois St | 70 | GW |